LOCUS       NM_007294               7224 bp    mRNA    linear   PRI 04-NOV-2010
DEFINITION  Homo sapiens breast cancer 1, early onset (BRCA1), transcript
            variant 1, mRNA.
ACCESSION   NM_007294
VERSION     NM_007294.3  GI:237757283
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7224)
  AUTHORS   Orban,T.I. and Olah,E.
  TITLE     Emerging roles of BRCA1 alternative splicing
  JOURNAL   MP, Mol. Pathol. 56 (4), 191-197 (2003)
   PUBMED   12890739
  REMARK    Review article
REFERENCE   2  (bases 1 to 7224)
  AUTHORS   Orban,T.I. and Olah,E.
  TITLE     Expression profiles of BRCA1 splice variants in asynchronous and in
            G1/S synchronized tumor cell lines
  JOURNAL   Biochem. Biophys. Res. Commun. 280 (1), 32-38 (2001)
   PUBMED   11162473
REFERENCE   3  (bases 1 to 7224)
  AUTHORS   Paterson,J.W.
  TITLE     BRCA1: a review of structure and putative functions
  JOURNAL   Dis. Markers 13 (4), 261-274 (1998)
   PUBMED   9553742
  REMARK    Review article
REFERENCE   4  (bases 1 to 7224)
  AUTHORS   Xu,C.F., Chambers,J.A., Nicolai,H., Brown,M.A., Hujeirat,Y.,
            Mohammed,S., Hodgson,S., Kelsell,D.P., Spurr,N.K., Bishop,D.T. and
            Solomon,E.
  TITLE     Mutations and alternative splicing of the BRCA1 gene in UK
            breast/ovarian cancer families
  JOURNAL   Genes Chromosomes Cancer 18 (2), 102-110 (1997)
   PUBMED   9115959
REFERENCE   5  (bases 1 to 7224)
  AUTHORS   Wilson,C.A., Payton,M.N., Elliott,G.S., Buaas,F.W., Cajulis,E.E.,
            Grosshans,D., Ramos,L., Reese,D.M., Slamon,D.J. and Calzone,F.J.
  TITLE     Differential subcellular localization, expression and biological
            toxicity of BRCA1 and the splice variant BRCA1-delta11b
  JOURNAL   Oncogene 14 (1), 1-16 (1997)
   PUBMED   9010228
REFERENCE   6  (bases 1 to 7224)
  AUTHORS   Thakur,S., Zhang,H.B., Peng,Y., Le,H., Carroll,B., Ward,T., Yao,J.,
            Farid,L.M., Couch,F.J., Wilson,R.B. and Weber,B.L.
  TITLE     Localization of BRCA1 and a splice variant identifies the nuclear
            localization signal
  JOURNAL   Mol. Cell. Biol. 17 (1), 444-452 (1997)
   PUBMED   8972225
REFERENCE   7  (bases 1 to 7224)
  AUTHORS   Lu,M., Conzen,S.D., Cole,C.N. and Arrick,B.A.
  TITLE     Characterization of functional messenger RNA splice variants of
            BRCA1 expressed in nonmalignant and tumor-derived breast cells
  JOURNAL   Cancer Res. 56 (20), 4578-4581 (1996)
   PUBMED   8840964
REFERENCE   8  (bases 1 to 7224)
  AUTHORS   Holt,J.T., Thompson,M.E., Szabo,C., Robinson-Benion,C.,
            Arteaga,C.L., King,M.C. and Jensen,R.A.
  TITLE     Growth retardation and tumour inhibition by BRCA1
  JOURNAL   Nat. Genet. 12 (3), 298-302 (1996)
   PUBMED   8589721
  REMARK    Erratum:[Nat Genet 1998 May;19(1):102]
REFERENCE   9  (bases 1 to 7224)
  AUTHORS   Xu,C.F., Brown,M.A., Chambers,J.A., Griffiths,B., Nicolai,H. and
            Solomon,E.
  TITLE     Distinct transcription start sites generate two forms of BRCA1 mRNA
  JOURNAL   Hum. Mol. Genet. 4 (12), 2259-2264 (1995)
   PUBMED   8634696
REFERENCE   10 (bases 1 to 7224)
  AUTHORS   Miki,Y., Swensen,J., Shattuck-Eidens,D., Futreal,P.A., Harshman,K.,
            Tavtigian,S., Liu,Q., Cochran,C., Bennett,L.M., Ding,W. et al.
  TITLE     A strong candidate for the breast and ovarian cancer susceptibility
            gene BRCA1
  JOURNAL   Science 266 (5182), 66-71 (1994)
   PUBMED   7545954
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL701927.1, U14680.1,
            BC072418.1, BU617173.1 and BU679389.1.
            This sequence is a reference standard in the RefSeqGene project.
            On May 19, 2009 this sequence version replaced gi:63252871.
            
            Summary: This gene encodes a nuclear phosphoprotein that plays a
            role in maintaining genomic stability, and it also acts as a tumor
            suppressor. The encoded protein combines with other tumor
            suppressors, DNA damage sensors, and signal transducers to form a
            large multi-subunit protein complex known as the BRCA1-associated
            genome surveillance complex (BASC). This gene product associates
            with RNA polymerase II, and through the C-terminal domain, also
            interacts with histone deacetylase complexes. This protein thus
            plays a role in transcription, DNA repair of double-stranded
            breaks, and recombination. Mutations in this gene are responsible
            for approximately 40% of inherited breast cancers and more than 80%
            of inherited breast and ovarian cancers. Alternative splicing plays
            a role in modulating the subcellular localization and physiological
            function of this gene. Many alternatively spliced transcript
            variants, some of which are disease-associated mutations, have been
            described for this gene, but the full-length natures of only some
            of these variants has been described. A related pseudogene, which
            is also located on chromosome 17, has been identified. [provided by
            RefSeq].
            
            Transcript Variant: This variant (1, also known as BRCA1a)
            represents the more frequently occurring transcript. It encodes the
            full-length BRCA1 protein (isoform 1), which is also known as p220.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the
            Entrez Gene record to access additional publications.
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AL701927.1         1-143
            144-5824            U14680.1           31-5711
            5825-6573           BC072418.1         2401-3149
            6574-7205           BU617173.1         19-650              c
            7206-7224           BU679389.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..7224
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21"
     gene            1..7224
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /note="breast cancer 1, early onset"
                     /db_xref="GeneID:672"
                     /db_xref="HGNC:1100"
                     /db_xref="HPRD:00218"
                     /db_xref="MIM:113705"
     exon            1..213
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=1a
     misc_feature    93
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /note="alternative transcription start site"
     STS             184..1651
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /db_xref="UniSTS:482866"
     exon            214..312
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=2
     CDS             233..5824
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /note="isoform 1 is encoded by transcript variant 1;
                     breast and ovarian cancer susceptibility protein 1; RING
                     finger protein 53; breast and ovarian cancer
                     sususceptibility protein; breast cancer type 1
                     susceptibility protein; BRCA1/BRCA2-containing complex,
                     subunit 1"
                     /codon_start=1
                     /product="breast cancer type 1 susceptibility protein
                     isoform 1"
                     /protein_id="NP_009225.1"
                     /db_xref="GI:6552299"
                     /db_xref="CCDS:CCDS11453.1"
                     /db_xref="GeneID:672"
                     /db_xref="HGNC:1100"
                     /db_xref="HPRD:00218"
                     /db_xref="MIM:113705"
                     /translation="MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFC
                     KFCMLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYA
                     NSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLG
                     TVRTLRTKQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISL
                     DSAKKAACEFSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGT
                     NTHASSLQHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTP
                     STEKKVDLNADPLCERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDEL
                     LGSDDSHDGESESNAKVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSK
                     SVESNIEDKIFGKTYRKKASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRP
                     TSGLHPEDFIKKADLAVQKTPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEK
                     NPNPIESLEKESAFKTKAEPISSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALE
                     LVVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSN
                     KPNEQTSKRHDSDTFPELKLTNAPGSFTKCSNTSELKEFVNPSLPREEKEEKLETVKV
                     SNNAEDPKDLMLSGERVLQTERSVESSSISLVPGTDYGTQESISLLEVSTLGKAKTEP
                     NKCVSQCAAFENPKGLIHGCSKDNRNDTEGFKYPLGHEVNHSRETSIEMEESELDAQY
                     LQNTFKVSKRQSFAPFSNPGNAEEECATFSAHSGSLKKQSPKVTFECEQKEENQGKNE
                     SNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIKGGSRFCLSSQFRGNETGLITPNKHG
                     LLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMGNENIPSTVSTISRNN
                     IRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDENIQAELGRNRGPKLNAMLRLGV
                     LQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSSHASQVC
                     SETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELSRSPSPFTHTHLAQGYRR
                     GAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTVATECLSKNTEENLLS
                     LKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGS
                     SKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSV
                     SEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDS
                     SALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVE
                     RSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSY
                     LPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAES
                     AQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKF
                     ARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKER
                     KMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMV
                     QLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSV
                     ALYQCQELDTYLIPQIPHSHY"
     exon            313..366
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=3
     exon            367..444
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=4b
     exon            445..533
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=5
     exon            534..673
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=6
     exon            674..779
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=7a
     exon            780..825
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=8
     exon            826..902
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=9
     exon            903..4328
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=10b
     STS             909..1077
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="GDB:454227"
                     /db_xref="UniSTS:157424"
     STS             996..1234
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="GDB:454278"
                     /db_xref="UniSTS:157425"
     STS             1159..1436
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="GDB:454349"
                     /db_xref="UniSTS:157426"
     STS             1299..1543
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="GDB:454353"
                     /db_xref="UniSTS:157427"
     STS             1465..1730
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="GDB:454372"
                     /db_xref="UniSTS:157428"
     STS             1685..1947
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="GDB:454381"
                     /db_xref="UniSTS:157429"
     STS             1844..2087
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="GDB:454417"
                     /db_xref="UniSTS:157430"
     STS             2031..2329
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="GDB:454421"
                     /db_xref="UniSTS:157431"
     STS             2255..2510
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="GDB:454425"
                     /db_xref="UniSTS:157432"
     STS             2394..2617
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="GDB:454429"
                     /db_xref="UniSTS:157433"
     STS             2561..2830
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="GDB:454433"
                     /db_xref="UniSTS:157434"
     STS             2748..3061
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="GDB:454437"
                     /db_xref="UniSTS:157435"
     STS             2774..3016
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="PMC13918P1"
                     /db_xref="UniSTS:270877"
     STS             3013..3318
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="GDB:454441"
                     /db_xref="UniSTS:157436"
     STS             3284..3661
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="GDB:454446"
                     /db_xref="UniSTS:157437"
     STS             3526..3850
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="GDB:454450"
                     /db_xref="UniSTS:157438"
     STS             3796..4084
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="BRCA1"
                     /db_xref="UniSTS:262743"
     STS             3799..4072
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="GDB:454454"
                     /db_xref="UniSTS:157439"
     STS             3808..4067
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="PMC310899P3"
                     /db_xref="UniSTS:272805"
     STS             3901..4196
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="G60034"
                     /db_xref="UniSTS:137300"
     STS             3909..4067
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="PMC310899P2"
                     /db_xref="UniSTS:272804"
     STS             3973..4181
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="GDB:454458"
                     /db_xref="UniSTS:157440"
     STS             4109..4326
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="GDB:454462"
                     /db_xref="UniSTS:157441"
     exon            4329..4417
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=11
     exon            4418..4589
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=12
     exon            4590..4716
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=14a
     exon            4717..4907
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=15
     exon            4908..5218
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=16
     exon            5219..5306
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=17
     exon            5307..5384
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=18
     exon            5385..5425
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=19
     exon            5426..5509
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=20
     exon            5510..5564
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=21
     exon            5565..5638
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=22
     exon            5639..5699
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=23
     exon            5700..7207
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /inference="alignment:Splign"
                     /number=24
     STS             5746..5881
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="PMC310899P11"
                     /db_xref="UniSTS:272801"
     STS             5872..6109
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="RH79896"
                     /db_xref="UniSTS:90392"
     STS             6374..7203
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
                     /standard_name="BRCA1_4046"
                     /db_xref="UniSTS:464465"
     polyA_signal    7182..7187
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
     polyA_site      7207
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PSCP;
                     RNF53"
ORIGIN      
        1 gtaccttgat ttcgtattct gagaggctgc tgcttagcgg tagccccttg gtttccgtgg
       61 caacggaaaa gcgcgggaat tacagataaa ttaaaactgc gactgcgcgg cgtgagctcg
      121 ctgagacttc ctggacgggg gacaggctgt ggggtttctc agataactgg gcccctgcgc
      181 tcaggaggcc ttcaccctct gctctgggta aagttcattg gaacagaaag aaatggattt
      241 atctgctctt cgcgttgaag aagtacaaaa tgtcattaat gctatgcaga aaatcttaga
      301 gtgtcccatc tgtctggagt tgatcaagga acctgtctcc acaaagtgtg accacatatt
      361 ttgcaaattt tgcatgctga aacttctcaa ccagaagaaa gggccttcac agtgtccttt
      421 atgtaagaat gatataacca aaaggagcct acaagaaagt acgagattta gtcaacttgt
      481 tgaagagcta ttgaaaatca tttgtgcttt tcagcttgac acaggtttgg agtatgcaaa
      541 cagctataat tttgcaaaaa aggaaaataa ctctcctgaa catctaaaag atgaagtttc
      601 tatcatccaa agtatgggct acagaaaccg tgccaaaaga cttctacaga gtgaacccga
      661 aaatccttcc ttgcaggaaa ccagtctcag tgtccaactc tctaaccttg gaactgtgag
      721 aactctgagg acaaagcagc ggatacaacc tcaaaagacg tctgtctaca ttgaattggg
      781 atctgattct tctgaagata ccgttaataa ggcaacttat tgcagtgtgg gagatcaaga
      841 attgttacaa atcacccctc aaggaaccag ggatgaaatc agtttggatt ctgcaaaaaa
      901 ggctgcttgt gaattttctg agacggatgt aacaaatact gaacatcatc aacccagtaa
      961 taatgatttg aacaccactg agaagcgtgc agctgagagg catccagaaa agtatcaggg
     1021 tagttctgtt tcaaacttgc atgtggagcc atgtggcaca aatactcatg ccagctcatt
     1081 acagcatgag aacagcagtt tattactcac taaagacaga atgaatgtag aaaaggctga
     1141 attctgtaat aaaagcaaac agcctggctt agcaaggagc caacataaca gatgggctgg
     1201 aagtaaggaa acatgtaatg ataggcggac tcccagcaca gaaaaaaagg tagatctgaa
     1261 tgctgatccc ctgtgtgaga gaaaagaatg gaataagcag aaactgccat gctcagagaa
     1321 tcctagagat actgaagatg ttccttggat aacactaaat agcagcattc agaaagttaa
     1381 tgagtggttt tccagaagtg atgaactgtt aggttctgat gactcacatg atggggagtc
     1441 tgaatcaaat gccaaagtag ctgatgtatt ggacgttcta aatgaggtag atgaatattc
     1501 tggttcttca gagaaaatag acttactggc cagtgatcct catgaggctt taatatgtaa
     1561 aagtgaaaga gttcactcca aatcagtaga gagtaatatt gaagacaaaa tatttgggaa
     1621 aacctatcgg aagaaggcaa gcctccccaa cttaagccat gtaactgaaa atctaattat
     1681 aggagcattt gttactgagc cacagataat acaagagcgt cccctcacaa ataaattaaa
     1741 gcgtaaaagg agacctacat caggccttca tcctgaggat tttatcaaga aagcagattt
     1801 ggcagttcaa aagactcctg aaatgataaa tcagggaact aaccaaacgg agcagaatgg
     1861 tcaagtgatg aatattacta atagtggtca tgagaataaa acaaaaggtg attctattca
     1921 gaatgagaaa aatcctaacc caatagaatc actcgaaaaa gaatctgctt tcaaaacgaa
     1981 agctgaacct ataagcagca gtataagcaa tatggaactc gaattaaata tccacaattc
     2041 aaaagcacct aaaaagaata ggctgaggag gaagtcttct accaggcata ttcatgcgct
     2101 tgaactagta gtcagtagaa atctaagccc acctaattgt actgaattgc aaattgatag
     2161 ttgttctagc agtgaagaga taaagaaaaa aaagtacaac caaatgccag tcaggcacag
     2221 cagaaaccta caactcatgg aaggtaaaga acctgcaact ggagccaaga agagtaacaa
     2281 gccaaatgaa cagacaagta aaagacatga cagcgatact ttcccagagc tgaagttaac
     2341 aaatgcacct ggttctttta ctaagtgttc aaataccagt gaacttaaag aatttgtcaa
     2401 tcctagcctt ccaagagaag aaaaagaaga gaaactagaa acagttaaag tgtctaataa
     2461 tgctgaagac cccaaagatc tcatgttaag tggagaaagg gttttgcaaa ctgaaagatc
     2521 tgtagagagt agcagtattt cattggtacc tggtactgat tatggcactc aggaaagtat
     2581 ctcgttactg gaagttagca ctctagggaa ggcaaaaaca gaaccaaata aatgtgtgag
     2641 tcagtgtgca gcatttgaaa accccaaggg actaattcat ggttgttcca aagataatag
     2701 aaatgacaca gaaggcttta agtatccatt gggacatgaa gttaaccaca gtcgggaaac
     2761 aagcatagaa atggaagaaa gtgaacttga tgctcagtat ttgcagaata cattcaaggt
     2821 ttcaaagcgc cagtcatttg ctccgttttc aaatccagga aatgcagaag aggaatgtgc
     2881 aacattctct gcccactctg ggtccttaaa gaaacaaagt ccaaaagtca cttttgaatg
     2941 tgaacaaaag gaagaaaatc aaggaaagaa tgagtctaat atcaagcctg tacagacagt
     3001 taatatcact gcaggctttc ctgtggttgg tcagaaagat aagccagttg ataatgccaa
     3061 atgtagtatc aaaggaggct ctaggttttg tctatcatct cagttcagag gcaacgaaac
     3121 tggactcatt actccaaata aacatggact tttacaaaac ccatatcgta taccaccact
     3181 ttttcccatc aagtcatttg ttaaaactaa atgtaagaaa aatctgctag aggaaaactt
     3241 tgaggaacat tcaatgtcac ctgaaagaga aatgggaaat gagaacattc caagtacagt
     3301 gagcacaatt agccgtaata acattagaga aaatgttttt aaagaagcca gctcaagcaa
     3361 tattaatgaa gtaggttcca gtactaatga agtgggctcc agtattaatg aaataggttc
     3421 cagtgatgaa aacattcaag cagaactagg tagaaacaga gggccaaaat tgaatgctat
     3481 gcttagatta ggggttttgc aacctgaggt ctataaacaa agtcttcctg gaagtaattg
     3541 taagcatcct gaaataaaaa agcaagaata tgaagaagta gttcagactg ttaatacaga
     3601 tttctctcca tatctgattt cagataactt agaacagcct atgggaagta gtcatgcatc
     3661 tcaggtttgt tctgagacac ctgatgacct gttagatgat ggtgaaataa aggaagatac
     3721 tagttttgct gaaaatgaca ttaaggaaag ttctgctgtt tttagcaaaa gcgtccagaa
     3781 aggagagctt agcaggagtc ctagcccttt cacccataca catttggctc agggttaccg
     3841 aagaggggcc aagaaattag agtcctcaga agagaactta tctagtgagg atgaagagct
     3901 tccctgcttc caacacttgt tatttggtaa agtaaacaat ataccttctc agtctactag
     3961 gcatagcacc gttgctaccg agtgtctgtc taagaacaca gaggagaatt tattatcatt
     4021 gaagaatagc ttaaatgact gcagtaacca ggtaatattg gcaaaggcat ctcaggaaca
     4081 tcaccttagt gaggaaacaa aatgttctgc tagcttgttt tcttcacagt gcagtgaatt
     4141 ggaagacttg actgcaaata caaacaccca ggatcctttc ttgattggtt cttccaaaca
     4201 aatgaggcat cagtctgaaa gccagggagt tggtctgagt gacaaggaat tggtttcaga
     4261 tgatgaagaa agaggaacgg gcttggaaga aaataatcaa gaagagcaaa gcatggattc
     4321 aaacttaggt gaagcagcat ctgggtgtga gagtgaaaca agcgtctctg aagactgctc
     4381 agggctatcc tctcagagtg acattttaac cactcagcag agggatacca tgcaacataa
     4441 cctgataaag ctccagcagg aaatggctga actagaagct gtgttagaac agcatgggag
     4501 ccagccttct aacagctacc cttccatcat aagtgactct tctgcccttg aggacctgcg
     4561 aaatccagaa caaagcacat cagaaaaagc agtattaact tcacagaaaa gtagtgaata
     4621 ccctataagc cagaatccag aaggcctttc tgctgacaag tttgaggtgt ctgcagatag
     4681 ttctaccagt aaaaataaag aaccaggagt ggaaaggtca tccccttcta aatgcccatc
     4741 attagatgat aggtggtaca tgcacagttg ctctgggagt cttcagaata gaaactaccc
     4801 atctcaagag gagctcatta aggttgttga tgtggaggag caacagctgg aagagtctgg
     4861 gccacacgat ttgacggaaa catcttactt gccaaggcaa gatctagagg gaacccctta
     4921 cctggaatct ggaatcagcc tcttctctga tgaccctgaa tctgatcctt ctgaagacag
     4981 agccccagag tcagctcgtg ttggcaacat accatcttca acctctgcat tgaaagttcc
     5041 ccaattgaaa gttgcagaat ctgcccagag tccagctgct gctcatacta ctgatactgc
     5101 tgggtataat gcaatggaag aaagtgtgag cagggagaag ccagaattga cagcttcaac
     5161 agaaagggtc aacaaaagaa tgtccatggt ggtgtctggc ctgaccccag aagaatttat
     5221 gctcgtgtac aagtttgcca gaaaacacca catcacttta actaatctaa ttactgaaga
     5281 gactactcat gttgttatga aaacagatgc tgagtttgtg tgtgaacgga cactgaaata
     5341 ttttctagga attgcgggag gaaaatgggt agttagctat ttctgggtga cccagtctat
     5401 taaagaaaga aaaatgctga atgagcatga ttttgaagtc agaggagatg tggtcaatgg
     5461 aagaaaccac caaggtccaa agcgagcaag agaatcccag gacagaaaga tcttcagggg
     5521 gctagaaatc tgttgctatg ggcccttcac caacatgccc acagatcaac tggaatggat
     5581 ggtacagctg tgtggtgctt ctgtggtgaa ggagctttca tcattcaccc ttggcacagg
     5641 tgtccaccca attgtggttg tgcagccaga tgcctggaca gaggacaatg gcttccatgc
     5701 aattgggcag atgtgtgagg cacctgtggt gacccgagag tgggtgttgg acagtgtagc
     5761 actctaccag tgccaggagc tggacaccta cctgataccc cagatccccc acagccacta
     5821 ctgactgcag ccagccacag gtacagagcc acaggacccc aagaatgagc ttacaaagtg
     5881 gcctttccag gccctgggag ctcctctcac tcttcagtcc ttctactgtc ctggctacta
     5941 aatattttat gtacatcagc ctgaaaagga cttctggcta tgcaagggtc ccttaaagat
     6001 tttctgcttg aagtctccct tggaaatctg ccatgagcac aaaattatgg taatttttca
     6061 cctgagaaga ttttaaaacc atttaaacgc caccaattga gcaagatgct gattcattat
     6121 ttatcagccc tattctttct attcaggctg ttgttggctt agggctggaa gcacagagtg
     6181 gcttggcctc aagagaatag ctggtttccc taagtttact tctctaaaac cctgtgttca
     6241 caaaggcaga gagtcagacc cttcaatgga aggagagtgc ttgggatcga ttatgtgact
     6301 taaagtcaga atagtccttg ggcagttctc aaatgttgga gtggaacatt ggggaggaaa
     6361 ttctgaggca ggtattagaa atgaaaagga aacttgaaac ctgggcatgg tggctcacgc
     6421 ctgtaatccc agcactttgg gaggccaagg tgggcagatc actggaggtc aggagttcga
     6481 aaccagcctg gccaacatgg tgaaacccca tctctactaa aaatacagaa attagccggt
     6541 catggtggtg gacacctgta atcccagcta ctcaggtggc taaggcagga gaatcacttc
     6601 agcccgggag gtggaggttg cagtgagcca agatcatacc acggcactcc agcctgggtg
     6661 acagtgagac tgtggctcaa aaaaaaaaaa aaaaaaagga aaatgaaact agaagagatt
     6721 tctaaaagtc tgagatatat ttgctagatt tctaaagaat gtgttctaaa acagcagaag
     6781 attttcaaga accggtttcc aaagacagtc ttctaattcc tcattagtaa taagtaaaat
     6841 gtttattgtt gtagctctgg tatataatcc attcctctta aaatataaga cctctggcat
     6901 gaatatttca tatctataaa atgacagatc ccaccaggaa ggaagctgtt gctttctttg
     6961 aggtgatttt tttcctttgc tccctgttgc tgaaaccata cagcttcata aataattttg
     7021 cttgctgaag gaagaaaaag tgtttttcat aaacccatta tccaggactg tttatagctg
     7081 ttggaaggac taggtcttcc ctagcccccc cagtgtgcaa gggcagtgaa gacttgattg
     7141 tacaaaatac gttttgtaaa tgttgtgctg ttaacactgc aaataaactt ggtagcaaac
     7201 acttccaaaa aaaaaaaaaa aaaa
//

